Efficacy of ellaOne® vs levonorgestrel

ellaOne® significantly reduces the risk of unintended pregnancy vs levonorgestrel.1

A meta-analysis of the two, large, head-to-head trials comparing ellaOne® with levonorgestrel showed that the risk of pregnancy was significantly reduced with ulipristal acetate compared to levonorgestrel :1

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For a woman who comes to you for help, what does this mean ?

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Her risk of getting pregnant is :

Intake within

  • 24h
  • 72h

of unprotected intercourse

  • With
    no intervention
  • With
    levonorgestrel
  • With
    ellaOne®
  • arrow
    5.5 %
    5.5 %
  • arrow
    2.3 %
    2.2 %
  • arrow
    0.9 %
    1.4 %

P- value: 0.035

P- value: 0.046

Two comparative non-inferiority studies showed ellaOne® is at least as effective in preventing pregnancy as levonorgestrel.1,2

 

References
1.Glasier AF et al. The Lancet 2010; 375: 555-562.
2.Creinin M et al. Obstet Gynecol 2006; 108(5): 1089–1097.
3.HRA Pharma Report. Women and emergency contraception in 2012. A European Survey.